<?xml version="1.0" encoding="utf-8"?><rss version="2.0" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Nycomed News RSS feed</title><link>http://www.nycomed.com/News.aspx</link><description>News</description><language>en</language><image><url>http://www.nycomed.com/~/media/Countries/www_nycomed_com/Settings/img_logo.ashx?20100422T1216486111</url><title>Nycomed News RSS feed</title><link>http://www.nycomed.com/News.aspx</link></image><atom:link href="http://www.nycomed.com/News.aspx?p=rss" rel="self" type="application/rss+xml" /><pubDate>Wed, 01 Sep 2010 08:47:49 GMT</pubDate><lastBuildDate>Wed, 01 Sep 2010 08:47:49 GMT</lastBuildDate><item><title>From Oranienburg to the rest of the world: global market launch of Daxas® (Roflumilast) kicks off in Germany</title><link>http://www.nycomed.com/News/News-Releases/2010/from-oranienburg-to-the-rest-of-the-world---global-market-launch-of-daxas.aspx</link><description><![CDATA[
		
First new substance class in the area of chronic obstructive pulmonary disease (COPD) in more than a decade 
New treatment option for 700,000 patients in Germany with severe COPD and chronic bronchitis 
Improves lung function and reduces exacerbation in combination with bronchodilator treatment 
Daxas® – a German success story: research and development in Konstanz; worldwide production in Oranienburg
 
Stefan Brinkmann, Managing Director of Nycomed GmbH, kicked off the German market launch of Daxas® (Roflumilast) in Oranienburg today, making Germany the first country to market the medicine. Daxas® is a proprietary selective phosphodiesterase 4 (PDE4) enzyme inhibitor that was developed by Nycomed to treat the progressive, life-threatening lung disease COPD. 
“This is a very special day for Nycomed in Germany, as Daxas allows us to offer a new treatment option to 700,000 patients in Germany. However, Daxas is also a success story for the German pharmaceutical industry. The product was researched and developed at our research facility in Konstanz and we are pleased that Nycomed Oranienburg was selected as the production site to supply the global market,” said Managing Director Stefan Brinkmann.
Daxas is indicated for maintenance treatment of severe COPD (FEV1 post-bronchodilator less than 50% predicted) associated with chronic bronchitis in adult patients with a history of frequent exacerbations as an add-on to bronchodilator treatment. COPD remains a significant area of unmet medical need. It is a progressive and irreversible lung disease resulting in difficulty in breathing. The disease is characterized by severe episodes of worsening, called exacerbations. According to World Health Organization (WHO) estimates, 80 million people have moderate to severe COPD worldwide. More than 3 million people died of COPD in 2005, which corresponds to 5% of all deaths globally. The WHO predicts that total deaths from COPD could increase by more than 30% in the next 10 years unless urgent action is taken to reduce the underlying risk factors, especially smoking. 
“There is indeed a great need for new COPD treatment options,” says Prof. Helgo Magnussen, medical director of Grosshansdorf Hospital's Centre for Pneumology and Thoracic Surgery. “The aim of COPD therapy is to prevent acute exacerbations while improving lung function and easing physical strain. The reduction of exacerbations is a key objective with regard to morbidity and mortality. Medications that are currently available have limited therapy success rates for COPD, and no existing therapies slow the progression of COPD or inhibit infections of the bronchioles or pulmonary tissue. Roflumilast offers a completely new pharmacological approach and makes a real contribution to improve current COPD treatment.”
Daxas offers the production facility in Oranienburg the opportunity to build on the successful developments seen in recent years. “Today, Oranienburg is a key production site within the global Nycomed network. Over the past several years we have succeeded in bringing in a number of key projects to this location, enabling us not only to significantly expand our capacities, but also to create jobs – 60 in the past year alone. Of course, Daxas is now our new signature product and we are proud to be able to supply the entire global market from Oranienburg,” said Plant Manager Dr. Hans-Christian Meyer.
In Germany, Daxas will be jointly marketed by Nycomed and MSD (known in the US and Canada as Merck &amp;amp; Co., Inc., based in Whitehouse Station, New Jersey, USA). Daxas will be launched in eight additional European countries and Canada by the end of this year. It is scheduled to be launched in other markets in 2011.
About Daxas® (roflumilast)
Daxas (roflumilast) is an orally administered selective phosphodiesterase 4 (PDE4) enzyme inhibitor, which has been shown to inhibit COPD related inflammation with a novel mode of action[1]. Daxas, a once-a-day oral tablet, is the first drug in a new class of treatment for COPD and the first oral anti-inflammatory treatment for COPD patients. Other pharmacological treatment for COPD patients includes the use of inhaled bronchodilators and inhaled corticosteroids.
About Nycomed
Nycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio.
Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialised through best-in-class partners, Nycomed plans to further strengthen its own position in key Asian markets.
With around 3,000 employees at its Konstanz, Singen, Oranienburg and Hamburg locations, Nycomed is one of Germany’s largest pharmaceutical companies. It covers the entire value chain in Germany, from research and development, through production and manufacturing, to marketing and sales.
Headquartered in Zurich, Switzerland, the company generated total sales of €3.2 billion in 2009 and an adjusted EBITDA of €1.1 billion.
For more information visit www.nycomed.com or www.nycomed.de.
 
[1] Hatzelmann A, Morcillo EJ, Lungarella G, Adnot S, Sanjar S, Beume R, Schudt C, Tenor H. The preclinical pharmacology of roflumilast – a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease, Pulmonary Pharmacology &amp;amp; Therapeutics (2010),doi: 10.1016/j.pupt.2010.03.011]]></description><pubDate>Wed, 01 Sep 2010 08:47:49 GMT</pubDate><guid>http://www.nycomed.com/News/News-Releases/2010/from-oranienburg-to-the-rest-of-the-world---global-market-launch-of-daxas.aspx</guid></item><item><title>Nycomed achieved significant milestone in second quarter 2010</title><link>http://www.nycomed.com/News/News-Releases/2010/nycomed-achieved-significant-milestone-in-second-quarter-2010.aspx</link><description><![CDATA[
		
Strong growth of Key Products and in emerging markets, especially Russia/CIS and Brazil. Impact from pantoprazole’s patent expiry in May 2009 in line with expectations. 
Total net turnover steady at -0.1% (-5.0% in local currencies) to €786.5 million (Q2/2009: €786.9 million); total net turnover in local currencies and excluding Pantoprazole up 14.7% in second quarter and up 11.2% in first half-year 2010 
Adjusted EBITDA decreased 22.5% (-27.3% in local currencies) to €197.4 million (Q2/2009: €254.8 million). 
Daxas® (roflumilast) approved in the EU; first market launches underway. 
Co-promotion agreement signed with Merck &amp;amp; Co., Inc., for Daxas® in selected markets. 
Validity of US patent for Protonix® (pantoprazole) confirmed by US District Court. 
TachoSil® approved by FDA for use in cardiovascular surgery. 
Imaging joint venture formed with GE Healthcare in Russia/CIS.
 
The financial results reported in this press release are related to Nycomed S.C.A. SICAR and comprise all of the Nycomed Group’s operations. The full interim report is available at http://www.nycomed.com/Investors/Reports
Nycomed’s performance in the second quarter was satisfactory, with sales of Key Products and in emerging markets, especially Russia/CIS and Brazil, continuing to help offset the revenue impact from the loss of exclusivity of pantoprazole. Turnover for the rest of the portfolio increased at double-digit rates. These results support Nycomed’s strategy of focusing on emerging markets and specialty products. In early July, Daxas® (roflumilast) received marketing authorisation in the EU. Product launches in the first EU markets, starting with Germany and the UK, are underway. 
The product portfolio was further strengthened by the FDA approval of TachoSil®, a surgical patch used in cardiovascular surgery. In June, the groundbreaking for the new manufacturing facility in Russia, demonstrating the strong commitment to this market, was celebrated. This followed news of Nycomed’s agreement with GE Healthcare to market diagnostic contrast agents in the Russia/CIS region.
The US District Court for the District of New Jersey has upheld jury findings, confirming that Nycomed’s US patent for Protonix® (pantoprazole) is valid and rejecting allegations by the defendants that the patent was invalid as obvious and invalid for double patenting. All issues regarding validity and infringement of Nycomed’s US patent for Protonix® have been decided by the District Court in Nycomed's and Pfizer's favor.
Håkan Björklund, CEO of Nycomed, commented on the company’s results:
“The results in the second quarter of 2010 were satisfactory and we achieved significant milestones, which are vital for the company’s future, including the EU marketing authorisation for Daxas, a once-a-day oral tablet, offering COPD patients and physicians a much needed new treatment.
Another important milestone was achieved in July when a judge confirmed the decision of a jury which found the US patent for Protonix valid. We will continue to vigorously pursue claims for damages caused by generics launched at-risk in the United States. 
2010 will be dominated by the effect of pantoprazole’s loss of exclusivity. In several markets, authorities have announced price cutting measures for pharmaceuticals. However, we expect further growth in our portfolio of Key Products and the introduction of Daxas in several markets. Efforts to enhance our emerging market presence, especially in Asia, are well underway.”
Key figures




 
Q2 2010(€m)
Q2 2009(€m)
Change   
H1 2010(€m)
H1 2009(€m)
Change   

Net turnover
786.5
786.9
-0.1%-5.0%(1)
1,562.9
1,626.8
-3.9%-7.0%(1)

Gross profitMargin
552.170.2%
576.073.2%
-4.1%
1,100.270.4%
1,198.073.6%
-8.2%

Operating profit (EBIT)
16.1
74.7
-78.4%
57.6
205.6
-72.0%

EBITDAMargin
188.524.0%
249.331.7%
-24.4%
401.025.7%
551.333.9%
-27.3%

Adjusted EBITDA Margin
197.425.1%
254.832.7%
-22.5%-27.3%(1)
430.427.5%
561.834.5%
-23.4%-26.0%(1)
(1) In local currencies 
Financial background
Adjusted EBITDA and EBITDA are key figures used in order to have a more comprehensive analysis of our operating performance and of our ability to service our debt. EBITDA means net income adjusted for net financial terms, income taxes, depreciation of tangible assets and amortisation of intangible assets. Adjusted EBITDA is EBITDA adjusted for unusual or non-recurring items not related to the future and ongoing business. For the second quarter 2010 the difference between EBITDA and adjusted EBITDA mainly comprises integration, projects and restructuring costs. 
About Nycomed
Nycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio.
Its R&amp;amp;D is structured around partnerships and in-licensing is a cornerstone of the company's growth strategy.
Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialised through best-in-class partners, Nycomed plans to further strengthen its own position in key Asian markets.
Headquartered in Zurich, Switzerland, the company generated total sales of €3.2 billion in 2009 and an adjusted EBITDA of €1.1 billion.
For more information visit www.nycomed.com]]></description><pubDate>Tue, 17 Aug 2010 07:42:48 GMT</pubDate><guid>http://www.nycomed.com/News/News-Releases/2010/nycomed-achieved-significant-milestone-in-second-quarter-2010.aspx</guid></item><item><title>Nycomed’s U.S. patent for Protonix® (pantoprazole) valid</title><link>http://www.nycomed.com/News/News-Releases/2010/Nycomeds%20US%20patent%20for%20Protonix%20pantoprazole%20valid.aspx</link><description><![CDATA[
		
Nycomed’s Protonix® patent found infringed and not obvious 
U.S. District Court for the District of New Jersey has uphold jury findings 
Nycomed will continue to vigorously pursue its damage claims
Nycomed announced today that Judge Jose L. Linares of the U.S. District Court for the District of New Jersey has confirmed the jury verdict in favor of Nycomed and Pfizer Inc. The decision upholds the jury verdict issued on April 23, 2010, confirming that the patent is valid and rejecting allegations by the defendants that the patent was invalid as obvious and invalid for double patenting. Against KUDCo, the US generic drug business of the Schwarz Pharma Group, which did not at-risk launch, final Judgment was entered as a result of Judge Jose L. Linares' rulings. 
All issues regarding validity and infringement of Nycomed’s U.S. patent for Protonix® (pantoprazole) have been decided by the District Court in Nycomed's and Pfizer's favor. 
Håkan Björklund, Chief Executive Officer of Nycomed, commented: “We are very pleased that the court recognized and acknowledged that our patent is valid. Patents represent the foundation of pharmaceutical innovation and are crucial to bring new medicines and treatments to patients who need them.” 
Nycomed now will continue to vigorously pursue its damage claims in this case, resulting from the launch of generic versions of Protonix® at-risk by Teva and Sun. In 2007, before Teva and Sun started their patent infringing generic sales, Protonix® sales reached USD 1.9 billion[1], and have since then decreased considerably. Nycomed will also seek a rapid adjudication of Teva’s and Sun's remaining miscellaneous unenforceability defenses which were, together with Nycomed’s damage claims, bifurcated from the first trial. 
The pantoprazole patent, U.S. Patent No. 4,758,579, is owned by Nycomed and licensed to Wyeth[2], and expires in January 2011 (including pediatric exclusivity). Nycomed and Wyeth had filed their original patent infringement lawsuit in May 2004. In late 2007, Teva Pharmaceutical Industries Ltd., launched a generic version of the product at-risk, followed by Sun Pharmaceutical Industries Ltd., in early 2008. 
[1] Wyeth Financial Report 2007[2] Wyeth became a wholly owned subsidiary of Pfizer Inc. (NYSE: PFE) on October 15, 2009.
About Protonix® (Pantoprazole) Protonix® (Pantoprazole) is a proton pump inhibitor (PPI) used to reduce or prevent the production of gastric acid. Pantoprazole is an effective treatment for conditions where gastric acid reduction is required. It reduces the symptoms of a number of illnesses including stomach and intestinal gastric ulcers, heartburn, Gastro-esophageal Reflux Disease (GERD), and other related gastrointestinal diseases. Pantoprazole is also effective in preventing NSAID-induced gastric ulcers and is used by patients undergoing long-term NSAID therapy.
About Nycomed Nycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio.
Its R&amp;amp;D is structured around partnerships and in-licensing is a cornerstone of the company's growth strategy.
Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialised through best-in-class partners, Nycomed plans to further strengthen its own position in key Asian markets.
Headquartered in Zurich, Switzerland, the company generated total sales of €3.2 billion in 2009 and an adjusted EBITDA of €1.1 billion.
For more information visit www.nycomed.com]]></description><pubDate>Mon, 19 Jul 2010 07:31:07 GMT</pubDate><guid>http://www.nycomed.com/News/News-Releases/2010/Nycomeds%20US%20patent%20for%20Protonix%20pantoprazole%20valid.aspx</guid></item><item><title>Nycomed’s novel anti-inflammatory therapy Daxas® (roflumilast) receives marketing authorisation in the European Union for patients with COPD</title><link>http://www.nycomed.com/News/News-Releases/2010/Nycomeds%20novel%20anti-inflammatory%20therapy%20Daxas%20receives%20marketing%20authorisation%20in%20EU.aspx</link><description><![CDATA[
		
Anti-inflammatory treatment aimed at patients with severe Chronic Obstructive Pulmonary Disease (COPD) associated with chronic bronchitis 
First new class of treatment for COPD in more than a decade 
Improves lung function and reduces exacerbations, when added to bronchodilator treatment
Nycomed today announced that the European Commission has granted marketing authorisation for Daxas® (roflumilast) in the European Union. Daxas® is a proprietary selective phosphodiesterase 4 (PDE4) enzyme inhibitor that has been developed by Nycomed for the treatment of COPD, a progressive, life-threatening lung disease.
Daxas® is indicated for maintenance treatment of severe COPD (FEV1 post-bronchodilator less than 50% predicted) associated with chronic bronchitis in adult patients with a history of frequent exacerbations as an add-on to bronchodilator treatment. Daxas, an oral tablet taken once a day, is the first drug in a new class and is expected to be launched soon in the first European countries, starting with Germany and the UK.
Commenting on today’s announcement, Guido Oelkers, Executive Vice President Commercial Operations at Nycomed, said: “Nycomed is very excited about the marketing authorisation for Daxas in the European Union. It is an important milestone for the company and very good news for people suffering from this life-threatening disease. The approval of Daxas offers clinicians and patients a much needed new treatment option alongside existing inhaled therapies.”
“There is a real need for new COPD treatment options”, added Professor Klaus F. Rabe, University Medical Centre Leiden, Netherlands. “Daxas is a novel therapy which improves lung function and most importantly reduces exacerbations. It has a unique mode of action which targets the underlying inflammation in COPD and is an important addition to the current options available to doctors and patients.” 
Neil Barnes, Professor of Respiratory Medicine at Barts and the London Hospital, London, UK, said: “We have a large number of patients who remain symptomatic and have frequent exacerbations despite existing treatments, and for that more severe end of the spectrum we need new therapeutic options. The main additional benefit of Daxas on top of what is already achieved with bronchodilators is to reduce the number of exacerbations, or flare ups, which are the events that really concern the patients who experience them. For patients with COPD associated with chronic bronchitis and a history of flare ups, Daxas can make a real contribution.”
The application to the EMA was based on encouraging results from four Phase III trials of roflumilast in the treatment of symptomatic COPD. In two pivotal placebo controlled, 12-month studies involving a total of over 3,000 patients with COPD, roflumilast demonstrated statistically significant improvements on both co-primary endpoints; moderate to severe exacerbations and pre-bronchodilator FEV1 [1]. The effect of Daxas was independent of concomitant use of long-acting beta2-agonist (LABA) [1]. Roflumilast also demonstrated a statistically significant improvement compared to placebo on lung function, in two supportive studies over a six month period when added to the commonly used long-acting bronchodilators tiotropium or salmeterol .
Full data from all four studies were published in The Lancet in August 2009 [1,2] and were presented at the annual European Respiratory Society (ERS) Congress in Vienna, Austria, in September 2009.
On April 26, 2010, Nycomed and Merck &amp;amp; Co., Inc. (based in Whitehouse Station, New Jersey and known as MSD outside the USA and Canada) announced that they had entered into an agreement to co-promote Daxas in France, Germany, Italy, Spain, Portugal and Canada. Nycomed will manufacture and distribute the finished product in all countries covered by the co-promotion agreement. In addition, the two companies have signed an exclusive distribution agreement for the commercialization of Daxas in the United Kingdom. Nycomed will supply finished product and has retained a co-promotion option.
Nycomed submitted a New Drug Application (NDA) to the US Food &amp;amp; Drug Administration (FDA) in July 2009 and has signed a collaboration and distribution agreement for Daxas in the US with Forest Laboratories, Inc. (NYSE: FRX) in August 2009.
About Daxas® (roflumilast)Daxas (roflumilast) is an orally administered selective phosphodiesterase 4 (PDE4) enzyme inhibitor, which has been shown to inhibit COPD related inflammation with a novel mode of action [3]. Daxas, a once-a-day oral tablet, is the first drug in a new class of treatment for COPD and the first oral anti-inflammatory treatment for COPD patients. Other pharmacological treatment for COPD patients includes the use of inhaled bronchodilators and inhaled corticosteroids.
About COPDCOPD remains a significant area of unmet medical need. It is a progressive and irreversible lung disease resulting in difficulty in breathing. The disease is characterized by severe episodes of worsening, called exacerbations. According to World Health Organization (WHO) estimates, 80 million people have moderate to severe COPD worldwide. More than 3 million people died of COPD in 2005, which corresponds to 5% of all deaths globally. The WHO predicts that total deaths from COPD could increase by more than 30% in the next 10 years unless urgent action is taken to reduce the underlying risk factors, especially smoking. (see http://www.who.int/respiratory/copd/burden/en/index.html)
About NycomedNycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio.
Its R&amp;amp;D is structured around partnerships and in-licensing is a cornerstone of the company's growth strategy.
Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialised through best-in-class partners, Nycomed plans to further strengthen its own position in key Asian markets.
Headquartered in Zurich, Switzerland, the company generated total sales of €3.2 billion in 2009 and an adjusted EBITDA of €1.1 billion.
For more information visit www.nycomed.com
  
[1] Calverley PMA, et al. Roflumilast treatment in symptomatic chronic obstructive pulmonary disease. The Lancet 2009: 374, 685–94
[2] Fabbri LM et al. Roflumilast improves lung function in patients with moderately severe chronic obstructive pulmonary disease treated with long acting bronchodilators. The Lancet 2009: 374, 695–703
[3] Hatzelmann A, Morcillo EJ, Lungarella G, Adnot S, Sanjar S, Beume R, Schudt C, Tenor H. The preclinical pharmacology of roflumilast – a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease, Pulmonary Pharmacology &amp;amp; Therapeutics (2010), doi: 10.1016/j.pupt.2010.03.011]]></description><pubDate>Tue, 06 Jul 2010 11:46:21 GMT</pubDate><guid>http://www.nycomed.com/News/News-Releases/2010/Nycomeds%20novel%20anti-inflammatory%20therapy%20Daxas%20receives%20marketing%20authorisation%20in%20EU.aspx</guid></item><item><title>Nycomed and Forest Laboratories receive complete FDA response letter for Roflumilast – no additional patient trials were requested</title><link>http://www.nycomed.com/News/News-Releases/2010/Nycomed%20and%20Forest%20Laboratories%20receive%20complete%20FDA%20response%20letter%20for%20Roflumilast.aspx</link><description><![CDATA[
		
				Nycomed and Forest Laboratories, Inc. (NYSE: FRX) today announced that the U.S. Food and Drug Administration (FDA) issued a complete response letter regarding the New Drug Application (NDA) for roflumilast (Daxas®). Roflumilast was reviewed as a potential treatment to reduce COPD exacerbations associated with chronic bronchitis in patients at risk for exacerbations. 
In the complete response letter the FDA requested certain additional information and analyses. No additional patient trials have been requested for the continued review of the NDA. Nycomed and Forest are committed to working with the FDA to address the outstanding matters and the companies anticipate a response to the FDA during the third calendar quarter of 2010.
On April 23, 2010, the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) published a positive opinion, recommending the approval of Daxas® in the European Union.
About COPD COPD is an under-diagnosed, progressive lung disease that is the fourth leading cause of death in the U.S, with mortality due to COPD continuing to increase over the past 30 years. Approximately 12 million people in the U.S. are currently diagnosed with COPD and an additional 14 million are likely to have the disease and not know. Of the patients diagnosed with COPD, over 80% or 9.8 million have COPD associated with chronic bronchitis.
Symptoms of COPD include breathlessness, chronic cough and excessive production of phlegm. A significant worsening of symptoms called an exacerbation can last several weeks and often requires substantial medical intervention, including hospitalization. Exacerbations can result in worsening health status, lung function decline, and increased risk of death. 
About Roflumilast (Daxas®) Roflumilast is a phosphodiesterase 4 (PDE4) enzyme inhibitor that targets the underlying inflammation associated with COPD. If approved, roflumilast, a once-a-day oral tablet, will be the first in a new class of treatment for COPD. Roflumilast is not a steroid.
About ForestForest Laboratories (NYSE: FRX) is a U.S.-based pharmaceutical company with a long track record of building partnerships and developing and marketing products that make a positive difference in people's lives. In addition to its well-established franchises in therapeutic areas of the central nervous and cardiovascular systems, Forest's current pipeline includes product candidates in all stages of development and across a wide range of therapeutic areas. The Company is headquartered in New York, NY. To learn more about Forest Laboratories, visit www.FRX.com.
Except for the historical information contained herein, this release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements involve a number of risks and uncertainties, including the difficulty of predicting FDA approvals, the acceptance and demand for new pharmaceutical products, the impact of competitive products and pricing, the timely development and launch of new products, and the risk factors listed from time to time in Forest Laboratories’ Annual Report on Form 10-K, Quarterly Report on Form 10-Q, and any subsequent SEC filings.
About Nycomed Nycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio.
Its R&amp;amp;D is structured around partnerships and in-licensing is a cornerstone of the company's growth strategy.
Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialised through best-in-class partners, Nycomed plans to further strengthen its own position in key Asian markets.
Headquartered in Zurich, Switzerland, the company generated total sales of €3.2 billion in 2009 and an adjusted EBITDA of €1.1 billion.
 ]]></description><pubDate>Sun, 16 May 2010 22:00:00 GMT</pubDate><guid>http://www.nycomed.com/News/News-Releases/2010/Nycomed%20and%20Forest%20Laboratories%20receive%20complete%20FDA%20response%20letter%20for%20Roflumilast.aspx</guid></item><item><title>Nycomed’s first quarter 2010 results confirm the direction</title><link>http://www.nycomed.com/News/News-Releases/2010/Nycomeds%20first%20quarter%202010%20results%20confirm%20the%20direction.aspx</link><description><![CDATA[
		
Strong growth of Key Products and in emerging markets. Impact of pantoprazole's patent expiry in May 2009 as expected. 
Total net turnover decreased 7.6% (-8.9% in local currencies) to €776.4 million (Q1/2009: €839.9 million). 
Adjusted EBITDA decreased 24.1% (-24.8% in local currencies) to €233.1 million (Q1/2009: €307.0 million). 
Daxas® (roflumilast) is advancing: Nycomed received a positive opinion from CHMP and signed a co-promotion agreement with Merck &amp;amp; Co., Inc. (MSD). 
TachoSil® received FDA approval and will be launched by US partner Baxter International Inc. in the second half of 2010. 
    
Nycomed's performance was driven by strong growth of Key Products and in most emerging markets. This overall positive performance could not fully offset the expected negative impact of pantoprazole's patent expiry in Europe. Daxas® (roflumilast) is advancing well: Nycomed received a positive opinion from the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP), recommending the approval of Daxas® in the European Union. With Merck &amp;amp; Co., Inc. (MSD) a co-promotion agreement for five European countries and Canada has been signed. 
Nycomed also made significant advancement in its partnerships: With the FDA approval of TachoSil®, Baxter International will be able to market this surgical patch in the United States. In Russia/CIS, an agreement with GE Healthcare to form a joint venture for the local sales, marketing and distribution of GE Healthcare's medical diagnostic contrast agents has been announced.
A jury in the U.S. District Court for the District of New Jersey held that the US pantoprazole (Protonix®) patent is not invalid. Nycomed and its US partner Pfizer Inc. are pleased with the jury's findings and announced that as soon as the decision is final the companies will be seeking the full measure of their damages.
Håkan Björklund, CEO Nycomed, commented on the company's results: "We saw a very satisfactory performance in the first quarter of 2010 confirming our direction. Both Key Products and the emerging markets are developing well.
With a positive opinion from the CHMP, we have cleared an important hurdle of the European approval process for Daxas. To further utilize the potential of Daxas, we have signed a co-promotion agreement with Merck for several European countries and Canada. All of this confirms our belief in the future of this product. We were disappointed with the outcome from the recent FDA Advisory Committee meeting that reviewed Daxas. However, we remain optimistic that concerns expressed by the Committee and the FDA can be satisfactorily resolved.
For 2010, we will see the full effect of pantoprazole's loss of exclusivity. In some markets we anticipate pressure on pharmaceuticals prices from authorities. We do expect further growth of our Key Products and in emerging markets and are preparing the launch of Daxas."





Q1 2010 (€m)
Q1 2009 (€m)
Change

Net turnover
776.4
839.9
-7.6%-8.9%(1)

Gross profitMargin
548.270.6%
622.074.1%
-11.9%

Operating profit (EBIT)
41.6
130.9
-68.2%

EBITDAMargin
212.627.4%
302.036.0%
-29.6%

Adjusted EBITDAMargin
233.130.0%
307.036.6%
-24.1%-24.8%(1)

Financial background
Adjusted EBITDA and EBITDA are key figures used in order to have a more comprehensive analysis of our operating performance and of our ability to service our debt. EBITDA means net income adjusted for net financial terms, income taxes, depreciation of tangible assets and amortisation of intangible assets. Adjusted EBITDA is EBITDA adjusted for unusual or non-recurring items not related to the future and ongoing business. For the first quarter 2010 the difference between EBITDA and adjusted EBITDA mainly comprises integration, projects and restructuring costs.
About Nycomed
Nycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio.
Its R&amp;amp;D is structured around partnerships and in-licensing is a cornerstone of the company's growth strategy.
Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialised through best-in-class partners, Nycomed plans to further strengthen its own position in key Asian markets.
Headquartered in Zurich, Switzerland, the company generated total sales of €3.2 billion in 2009 and an adjusted EBITDA of €1.1 billion.
For more information visit www.nycomed.com]]></description><pubDate>Tue, 11 May 2010 15:33:00 GMT</pubDate><guid>http://www.nycomed.com/News/News-Releases/2010/Nycomeds%20first%20quarter%202010%20results%20confirm%20the%20direction.aspx</guid></item><item><title>GE Healthcare and Nycomed to form joint venture to sell, market and distribute medical diagnostic contrast agents in Russia and CIS</title><link>http://www.nycomed.com/News/News-Releases/2010/GE%20Healthcare%20and%20Nycomed%20to%20form%20joint%20venture.aspx</link><description><![CDATA[
		
Joint venture shows commitment to growth in Russia &amp;amp; CIS 
Partners optimize distribution model for key market 
 
Moscow, 27 April, 2010 - GE Healthcare, a unit of General Electric Company (NYSE: GE), and Nycomed today announced the signing of an agreement to form a joint venture for the local sales, marketing and distribution of GE Healthcare's medical diagnostic contrast agents in Russia and the Commonwealth of Independent States (CIS). The joint venture is expected to become operational during the second half of 2010, following the satisfaction of customary conditions.
The agreement further reinforces GE Healthcare's and Nycomed's commitment to local investment and growth in Russia and the CIS, and comprises the formation of a new Moscow-based sales, marketing and distribution company. The new company will sell, market and distribute GE Healthcare Medical Diagnostics' computed tomography (CT), x-ray and magnetic resonance (MR) contrast media products, which are used to enhance a physician's ability to distinguish structures and tissues in medical imaging.
"This joint venture, with such a strong partner in Nycomed, signals GE Healthcare's firm plans to grow in this important strategic market of Russia and CIS," said Reinaldo Garcia, President &amp;amp; CEO of GE Healthcare for Europe, Middle East and Africa. "It will bring GE Healthcare closer to its customers in Russia and is further demonstration of the company's commitment to the Russian medical and healthcare community."
Håkan Björklund, Chief Executive Officer of Nycomed commented: "With GE Healthcare we found an ideal partner and this joint venture offers an excellent strategic fit and further strengthens Nycomed's commitment to the Russia-CIS region. The investment underlines our belief in the long-term prospects of the healthcare market in Russia-CIS and optimally serving this market is vital for Nycomed."
GE Healthcare's contrast media products are currently marketed in Russia and CIS through a distribution agreement with Nycomed, and the new joint venture is intended to further enhance the presence of these key products on the Russian and CIS markets. It is expected that the new company will have around 40 employees in its Moscow offices and across the region it serves. Further details of the agreement were not disclosed.
The announcement from GE Healthcare follows the company's 2009 announcement that it is partnering to produce in Moscow, Russia's first locally assembled advanced 16-slice computed tomography (CT) scanner, and the inauguration in the city of GE Healthcare's advanced medical technology Training Centre for physicians.
-ends-
Notes for editors 
About GE Healthcare 
GE Healthcare provides transformational medical technologies and services that are shaping a new age of patient care. Our broad expertise in medical imaging and information technologies, medical diagnostics, patient monitoring systems, drug discovery, biopharmaceutical manufacturing technologies, performance improvement and performance solutions services help our customers to deliver better care to more people around the world at a lower cost. In addition, we partner with healthcare leaders, striving to leverage the global policy change necessary to implement a successful shift to sustainable healthcare systems.
Our "healthymagination" vision for the future invites the world to join us on our journey as we continuously develop innovations focused on reducing costs, increasing access and improving quality and efficiency around the world. Headquartered in the United Kingdom, GE Healthcare is a $16 billion unit of General Electric Company (NYSE: GE). Worldwide, GE Healthcare employs more than 46,000 people committed to serving healthcare professionals and their patients in more than 100 countries.
For more information about GE Healthcare, visit our website at www.gehealthcare.com 
For our latest news, please visit http://newsroom.gehealthcare.com 
About Nycomed Nycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio.
Its R&amp;amp;D is structured around partnerships and in-licensing is a cornerstone of the company's growth strategy.
Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialised through best-in-class partners, Nycomed plans to further strengthen its own position in key Asian markets.
Headquartered in Zurich, Switzerland, the company generated total sales of €3.2 billion in 2009 and an adjusted EBITDA of €1.1 billion. 
For more information visit www.nycomed.com]]></description><pubDate>Mon, 26 Apr 2010 22:00:00 GMT</pubDate><guid>http://www.nycomed.com/News/News-Releases/2010/GE%20Healthcare%20and%20Nycomed%20to%20form%20joint%20venture.aspx</guid></item><item><title>Nycomed and Merck &amp; Co., Inc., announce commercialization agreements for Daxas® in Europe and Canada</title><link>http://www.nycomed.com/News/News-Releases/2010/Nycomed%20and%20Merck%20Co%20Inc%20announce%20commercialization%20agreements%20for%20Daxas%20in%20Europe%20and%20Canada.aspx</link><description><![CDATA[Zurich, Switzerland, and Whitehouse Station, N.J, April 26, 2010 - Nycomed and Merck &amp;amp; Co., Inc. (based in Whitehouse Station, New Jersey and known as MSD outside the USA and Canada) today announced that they have entered into a co-promotion agreement for Canada and certain European countries for the commercialization of Daxas® (roflumilast), an investigational once-daily tablet for patients with chronic obstructive pulmonary disease (COPD).  In addition, the two companies have signed an exclusive distribution agreement for the commercialization of Daxas® in the United Kingdom.

"This agreement with Nycomed for a late-stage PDE4 inhibitor candidate represents a strong strategic fit for Merck," said Kevin Ali, senior vice president and general manager Bone, Respiratory, Immunology and Dermatology franchise at Merck &amp;amp; Co., Inc.  "This builds upon Merck's leadership in the asthma and allergy marketplace and positions the company to leverage our well-trained sales force to target the rapidly growing unmet medical need of COPD."
"We are very pleased to have entered into this collaboration with Merck and we believe it's the best partner for us," said Håkan Björklund, Chief Executive Officer of Nycomed. "Nycomed's expertise in development of roflumilast, an important new approach for the treatment of COPD, Merck's customer oriented interactive commercial model and the regional synergies between the two companies will contribute to successfully bring Daxas to patients and doctors."
-more-
Under the terms of the agreement, Nycomed will receive an undisclosed upfront fee from Merck and is eligible for certain payments based on defined regulatory and commercialization milestones for Daxas. If approved by the relevant regulatory authorities, Merck and Nycomed will co-promote Daxas in France, Germany, Italy, Spain, Portugal, and Canada.  Nycomed will manufacture and distribute the finished product in all countries covered by the co-promotion agreement. In the United Kingdom Merck will have exclusive commercialization rights and Nycomed will supply finished product and has retained a co-promotion option. Further details of the agreement were not disclosed.
Nycomed filed marketing applications for Daxas with the European Medicines Agency (EMA) and Health Canada in 2009. In addition, Nycomed submitted a New Drug Application (NDA) to the US Food and Drug Administration (FDA) in July 2009. On April 23, 2010, Nycomed announced that it had received a positive opinion from the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP), recommending the approval of Daxas in the European Union.
About Roflumilast (Daxas®) Roflumilast is an orally administered phosphodiesterase 4 (PDE4) enzyme inhibitor targeting cells and mediators in the body believed to be important in the COPD disease process and related inflammatory diseases. If approved, roflumilast, a once-a-day oral tablet, will be the first in an entirely new class of treatment for COPD. It will also be the first oral anti-inflammatory treatment for COPD patients. Current treatment for COPD patients includes the use of inhaled bronchodilators and inhaled corticosteroids.
About Nycomed Nycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio.
Its R&amp;amp;D is structured around partnerships and in-licensing is a cornerstone of the company's growth strategy.
Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialized through best-in-
class partners, Nycomed plans to further strengthen its own position in key Asian markets.
-more-
Headquartered in Zurich, Switzerland, the company generated total sales of €3.2 billion in 2009 and an adjusted EBITDA of €1.1 billion.
For more information visit www.nycomed.com
About Merck &amp;amp; Co., Inc.Today's Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, and consumer care and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through far-reaching policies, programs and partnerships. Merck. Be well. For more information, visit www.merck.com.
Forward-Looking Statement This statement includes "forward-looking statements" within the meaning of the safe harbor provisions of the United States Private Securities Litigation Reform Act of 1995. Such statements may include, but are not limited to, statements about the benefits of the merger between Merck and Schering-Plough, including future financial and operating results, the combined company's plans, objectives, expectations and intentions and other statements that are not historical facts. Such statements are based upon the current beliefs and expectations of Merck's management and are subject to significant risks and uncertainties. Actual results may differ from those set forth in the forward-looking statements. The following factors, among others, could cause actual results to differ from those set forth in the forward-looking statements: the possibility that the expected synergies from the merger of Merck and Schering-Plough will not be realized, or will not be realized within the expected time period, due to, among other things, the impact of pharmaceutical industry regulation and pending legislation that could affect the pharmaceutical industry; the risk that the businesses will not be integrated successfully; disruption from the merger making it more difficult to maintain business and operational relationships; Merck's ability to accurately predict future market conditions; dependence on the effectiveness of Merck's patents and other protections for innovative products; the risk of new and changing regulation and health policies in the U.S. and internationally and the exposure to litigation and/or regulatory actions.
 -more-
 Merck undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in Merck's 2009 Annual Report on Form 10-K and the company's other filings with the Securities and Exchange Commission (SEC) available at the SEC's Internet site (www.sec.gov).]]></description><pubDate>Sun, 25 Apr 2010 22:00:00 GMT</pubDate><guid>http://www.nycomed.com/News/News-Releases/2010/Nycomed%20and%20Merck%20Co%20Inc%20announce%20commercialization%20agreements%20for%20Daxas%20in%20Europe%20and%20Canada.aspx</guid></item><item><title>Jury renders positive findings on US pantoprazole (Protonix®) patent</title><link>http://www.nycomed.com/News/News-Releases/2010/Jury%20renders%20positive%20findings%20on%20US%20pantoprazole%20Protonix%20patent.aspx</link><description><![CDATA[
		
      Nycomed and Pfizer Inc. confirmed today that a jury in the U.S. District Court for the District of New Jersey has rendered positive findings in a trial involving the main U.S. patent covering pantoprazole (Protonix®). 
    We are pleased with the jury's findings. The jury held that the patent was not invalid, rejecting allegations by several generic companies that the patent was obvious. Legal issues remain to be decided by the presiding judge, United States District Judge Jose L. Linares. The final decision of the court could be appealed. If we are successful at the end of this process, we will be seeking the full measure of our damages. 
    The pantoprazole patent, U.S. Patent No. 4,758,579, is owned by Nycomed and licensed to Wyeth1, and expires in January 2011 (including pediatric exclusivity). Nycomed and Wyeth had filed their patent infringement lawsuit against Teva and Sun Pharma in May 2004.
    1 Wyeth is a fully owned subsidiary of Pfizer Inc. (NYSE: PFE) as of October 15, 2009.
    
      About Protonix® (Pantoprazole) 
    Protonix® (Pantoprazole) is a proton pump inhibitor (PPI) used to reduce or prevent the production of gastric acid. Pantoprazole is an effective treatment for conditions where gastric acid reduction is required. It reduces the symptoms of a number of illnesses including stomach and intestinal gastric ulcers, heartburn, Gastro-esophageal Reflux Disease (GERD), and other related gastrointestinal diseases. Pantoprazole is also effective in preventing NSAID-induced gastric ulcers and is used by patients undergoing long-term NSAID therapy.
    
      About Nycomed 
    Nycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio.
    Its R&amp;amp;D is structured around partnerships and in-licensing is a cornerstone of the company's growth strategy.
    Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialised through best-in-class partners, Nycomed plans to further strengthen its own position in key Asian markets.
    Headquartered in Zurich, Switzerland, the company generated total sales of €3.2 billion in 2009 and an adjusted EBITDA of €1.1 billion.
    For more information visit www.nycomed.com
    
    ]]></description><pubDate>Thu, 22 Apr 2010 22:00:00 GMT</pubDate><guid>http://www.nycomed.com/News/News-Releases/2010/Jury%20renders%20positive%20findings%20on%20US%20pantoprazole%20Protonix%20patent.aspx</guid></item><item><title>Nycomed’s novel anti-inflammatory therapy Daxas® (roflumilast) recommended for approval in the European Union for patients with COPD </title><link>http://www.nycomed.com/News/News-Releases/2010/Nycomed%20novel%20anti-inflammatory%20therapy.aspx</link><description><![CDATA[
		First once-a-day oral tablet for treatment of Chronic Obstructive Pulmonary Disease (COPD)
First new class of treatment for COPD in more than a decade
Anti-inflammatory treatment aimed at patients with severe COPD associated with chronic bronchitis
Nycomed today announced that it has received a positive opinion from the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP), recommending the approval of Daxas® (roflumilast) in the European Union. Daxas® is a proprietary selective phosphodiesterase 4 (PDE4) enzyme inhibitor that has been developed by Nycomed for the treatment of COPD. 
Daxas® is recommended for maintenance treatment of severe COPD (FEV1 post-bronchodilator less than 50% predicted) associated with chronic bronchitis in adult patients with a history of frequent exacerbations as an add-on to bronchodilator treatment. With the granting of the marketing authorisation by the European Commission, Daxas, a once-a-day tablet, would become the first drug in a new class. Daxas is expected to be launched in the first European countries later this year.
Commenting on today's announcement, Anders Ullman, Executive Vice President Research and Development at Nycomed, said: "Nycomed is excited about the positive opinion of the CHMP recommending approval of Daxas in the European Union. Daxas is the first in a new class of oral agents to treat this life-threatening condition, offering clinicians and patients a much needed new treatment option alongside existing inhaled therapies."
The application to the EMA was based on encouraging results from four Phase III trials of roflumilast in the treatment of symptomatic COPD. In two pivotal placebo controlled, 12-month studies involving a total of over 3,000 patients with COPD, roflumilast demonstrated statistically significant improvements on both co-primary endpoints; moderate to severe exacerbations and pre-bronchodilator FEV1[1]. The effect of Daxas was independent of concomitant use of long-acting beta2-agonist (LABA)1. Roflumilast also demonstrated a statistically significant improvement compared to placebo on lung function, in two supportive studies over a six month period when added to the commonly used long-acting bronchodilators tiotropium or salmeterol[2].
Full data from all four studies were published in The Lancet in August 20091,2 and were presented at the annual European Respiratory Society (ERS) Congress in Vienna, Austria, in September 2009.
The complete summary of the positive CHMP opinion can be downloaded on the EMA website: http://www.ema.europa.eu/pdfs/human/press/pr/11026710en.pdf
Nycomed submitted a New Drug Application (NDA) to the US Food &amp;amp; Drug Administration (FDA) in July 2009 and has signed a collaboration and distribution agreement for Daxas in the US with Forest Laboratories, Inc. (NYSE: FRX) in August 2009.
About Daxas® (roflumilast)Daxas (roflumilast) is an orally administered selective phosphodiesterase 4 (PDE4) enzyme inhibitor, which has been shown to inhibit COPD related inflammation with a novel mode of action[3]. If approved, Daxas, a once-a-day tablet, will be the first drug in a new class of treatment for COPD. It will also be the first oral anti-inflammatory treatment for COPD patients. Current pharmacological treatment for COPD patients includes the use of inhaled bronchodilators and inhaled corticosteroids.
About COPDCOPD remains a significant area of unmet medical need. It is a progressive and irreversible lung disease resulting in difficulty in breathing. The disease is characterized by severe episodes of worsening, called exacerbations. According to World Health Organization (WHO) estimates, 80 million people have moderate to severe COPD worldwide. More than 3 million people died of COPD in 2005, which corresponds to 5% of all deaths globally. The WHO predicts that total deaths from COPD could increase by more than 30% in the next 10 years unless urgent action is taken to reduce the underlying risk factors, especially smoking.
(see http://www.who.int/respiratory/copd/burden/en/index.html)
About NycomedNycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio.
Its R&amp;amp;D is structured around partnerships and in-licensing is a cornerstone of the company's growth strategy.
Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialised through best-in-class partners, Nycomed plans to further strengthen its own position in key Asian markets.
Headquartered in Zurich, Switzerland, the company generated total sales of €3.2 billion in 2009 and an adjusted EBITDA of €1.1 billion.
For more information visit www.nycomed.com
Investors:Christian B. Seidelin, phone: +41 44 555 11 04
[1] Calverley PMA, et al. Roflumilast treatment in symptomatic chronic obstructive pulmonary disease. The Lancet 2009: 374, 685-94
[2] Fabbri LM et al. Roflumilast improves lung function in patients with moderately severe chronic obstructive pulmonary disease treated with long acting bronchodilators. The Lancet 2009: 374, 695-703
[3] Hatzelmann A, Morcillo EJ, Lungarella G, Adnot S, Sanjar S, Beume R, Schudt C, Tenor H. The preclinical pharmacology of roflumilast - a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease, Pulmonary Pharmacology &amp;amp; Therapeutics (2010), doi: 10.1016/j.pupt.2010.03.011

]]></description><pubDate>Thu, 22 Apr 2010 22:00:00 GMT</pubDate><guid>http://www.nycomed.com/News/News-Releases/2010/Nycomed%20novel%20anti-inflammatory%20therapy.aspx</guid></item></channel></rss>